This in general is a hard problem, but I recommend partnering with a University that has a strong info security and computer science program.
Crowdstrike has a very good system for detecting these "abnormal behavior" events at scale.
You will need to ingest a large amount of data, to a central log server that collects all of the MacOS logs.
With a machine learning approach, you will need a large list of anomalies
You can also try things like an "artificial ignorance" approach, where you alert on the first time a user runs a new program. But it will be hard to filter out
"bad software install" compared with regular installs.
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I'm also having this issues - freezing for up to 20 seconds, with a dual monitor system.
(Both external monitors are Dell HDMI monitors, but different resolutions)
MacOS Monterey 12.6.1 (just upgraded < 2 weeks ago)
MacBook Pro (16-inch 2019)
CPU: 2.4 Ghz 8-core Intel Core i9
Memory: 32 GB 2667 Mhz DDR4
Very frustrating