I have had a consistent bug since macOS Developer beta 9, and continuing with beta 10. First it happened with Myst from the GOG.com store, version 1.5.3, which is an Unreal Engine 4.26 title, and Apple Silicon native. Then it happened again with the latest release of Wonderbox from Apple Arcade, which is also now an Apple Silicon native title, and another Unreal Engine 4.26 title.
I will launch and play the game while a Skype video call is idling away on my other monitor. Within about 20 minutes of gameplay, the GPU will lock up, and all keyboard shortcuts will stop working. Within about one minute of that happening, the displays will shut off. At least with Wonderbox, the running game audio kept playing, but the game event loop did stop on its own, so the audio that persisted was the background music and the event sounds that were running when it locked up. The audio continues looping, so the game audio thread is still processing at this time.
At this point, the only access I had to the machine was to SSH into it with my iPad, and monitor processes with the top command, which showed that a crash was being logged. After that crash logged, I kill'd the game executable, which stopped the audio. Then I attempted to HUP WindowServer, which only killed it, and didn't bring back my displays.
I eventually sudo reboot'd the machine, which took a while to process, and when I booted back up, it reported that the machine apparently did panic, either before or during my attempted reboot.
The panic logged indicated that the GPU had crashed or something like that.
A snippet of the panic:
panic(cpu 4 caller 0xfffffe00152a95a8): GFX NMI FIQ - agx_interrupt(4) - failed to transition to state 0 (_iopStatus=7) RTKit: RTKit-1826.40.9.release - Client: not set
Feedback reported, reference number FB9704932