I picked up a new Mac Studio in March. It has no problem detecting my 3 brand new Samsung monitors but it can't remember the monitor set-up. After waking up from sleep, logging in and out of my photoshop login, and restarting, the Mac Studio persistently forgets which monitor is landscape, which is portrait, which monitor is the main display, and the arrangement (24" landscape on the left, 28.5" landscape in the center, 24" portrait on the right). It also loses the color profile and refresh rate. Sometimes it remembers settings for a few days but then it loses everything again and I have to begin the day by painstakingly restoring the set-up.
The situation did improve considerably when I installed Monterey 12.4, bought the new Apple keyboard, and activated touch ID. At the same time, I also rearranged the brand new USB-C cables from the monitors into the 2, 3 and 4 Thunderbolt slots on the back of the Mac Studio. I have found that I can "fix" the problem when it forgets the settings of the two external monitors by switching the USB-C cables from slot 2 to slot 4 and slot 4 to slot 2, putting the Mac to sleep, and then waking it again (hey presto, back to normal). However, the whole thing comes crashing down if I remove the main monitor cable from slot 3 (to use it as an external display for my MacBook). I do realize this makes no sense because the Mac Studio should be oblivious to the order in which the monitors are plugged in. However, IRL that doesn't seem to be the case. The Mac Studio wants the main monitor in the middle between the two external monitors.
I love this machine. I came up from a 2012 iMac so getting a Mac Studio is like moving from impulse drive to warp drive. Since I discovered the slot-switching trick I'm spending half an hour a week on the problem instead of half an hour a day. BUT it's still a real time sink and disruptor to workflow. I wish I understood why there is no "Save these settings" button in Display preferences.