I have this issue. If you too have this issue, can you please go here and report it: https://discussions.apple.com/thread/253303875 Posting on the developer forums, may not be the best way to raise awareness to Apple about this issue. In order to try and get this issue resolved as quickly as possible, it needs flagging in the correct places. Essentially, Monterey has broken support for a WIDE number of USB Hubs. Some USB Hubs work but certain ports on the hub do not, some Hubs do not work at all. For me, USB-C & HDMI work on the hub, but my USB 3.0 port will only power devices and there appears to be no data transfer. This issue is absolutely a Monterey bug. My devices were working fine prior to upgrading, and I have been able to replicate the issue and narrow it down by testing against a device that does not have Monterey installed.