Checking back in with a solution that worked for me. 2019 16” MBP i9 64RAM TLDR; in Audio MIDI setup, set everything to 44.1 (dont forget input and output settings) if that doesn’t help try a different sample rate. I make music with several DAWs and regardless of the software, interface, cables etc I’d get digital distortion out of nowhere and it would print onto recordings. Recently I took it in and thankfully the apple tech was also a music guy and knew exactly what I was referring to. He checked everything and hardware had nothing to do with mine. I wiped the entire mac when I got home, got the new OS, downloaded just StudioOne, Universal Control for my Presonus HD2, and ToneX. Deleted the audio PLISTs and restarted. quit and reset the coreaudio in activity manager. And it still happened. Lastly I opened Audio MIDI setup and on a whim set the mic, speakers, my interface, and even my two monitor screens to 44.1 and it solved everything. I am not sure why but I will be contacting both presonus and apple about it because I’d like have the option to record and listen at higher rate if I choose to. Also looking into getting a rack mounted external clock and maybe that could help too because it directly had to do with sample rates conflicting even though I wasn’t using some like internal speakers sample rate in a ableton session should have nothing to do with each other when I’m using an interface and studio monitors. Good luck all, I understand how frustrating this issue is.

2019 intel 16” MBP. I have encountered those short digital distortion blips when using any type of DAW on interface. Disappeared for couple years and now it’s back. Totally ruins any type of guitar tracking or IR making process. I’ve ruled out any sample rate, buffer size, cables or external devices. I am bringing it to Apple in a couple days and will hopefully have an answer.