Mac mini M1, BenQ 4k on USB-C and Dell 2k on HDMI (rotated 90 deg.). Scaling is 2nd. highest.
Quite often the scaling on the 4k monitor is automatically lowered to 2nd. lowest, but without scaling the display itself. This means I only see a part of the desktop, and I'm not able to get the Dock or anything else. Most often the 2k display stays a selected scaling, so I can access the dock from here and launch SysPref / Display. I then have to set scaling to highest, and then lower it to my choice of the 2nd highest.
If I'm unlucky that scaling is also messed up on the 2k screen I have to restart the Mac.
Really annoying as it happens quite often.