We are experiencing the same thing in our production environment. We are heavily relying on creating audio from text on our website, using Microsoft cognitive services. We need to use the same setup as csheff is referring to (https://lastmjs.github.io/safari-object-url-test/), but our audio played using window.URL.createObjectURL is stopped/muted early. Length of the audio file is correct, but the audio stops outputting sound towards the end of the file. Only appearing on 15.4. Kind of a big problem for us since we don't see a workaround for this issue.