Having this same issue. A workaround that just worked for me was to: Open System Preferences Click on Displays If not already selected, select Scaled under Resolution: Choose a different scaling from the one that you current have selected Switch back to your preferred scaling If previously on Default for display, re-select that option Once I switched back to Default (in my case), Mission Control started working as expected. For reference, I'm running macOS Big Sur 11.4 (20F71) on a 2019 MacBook Pro 16 with a Radeon 5500M GPU. I haven't updated to 11.5.x yet because I use this laptop for DJing and upgrading is hit or miss for support with my mixer and DJ software. Hope this helps someone. Cheers, Flux aka Andy

@rafablues94 same with me. The dropouts are less frequent and for a shorter duration with 11.3 and newer iBridge firmware, but they are still occurring. Not sure if it’s good, but interesting to know that this item is not just happening on Intel Macs. Thanks for the reply. Cheers.

For those having similar issues to this one, it appears that Big Sur 11.3 (or a change to the Boot ROM/iBridge, or something else) has lessened the frequency of drop outs for my hardware. It's still not perfect, but a little better. The drop outs only occur for about 0.03 secs where before they were much longer. Connection path: DS1 -- CalDigit TS3+ Thunderbolt hub -- MBP16 Here's my config: Hardware Overview:   Model Name: MacBook Pro   Model Identifier: MacBookPro16,1   Processor Name: 8-Core Intel Core i9   Processor Speed: 2.4 GHz   Number of Processors: 1   Total Number of Cores: 8   L2 Cache (per Core): 256 KB   L3 Cache: 16 MB   Hyper-Threading Technology: Enabled   Memory: 64 GB   System Firmware Version: 1554.100.64.0.0 (iBridge: 18.16.14556.0.0,0) System Software Overview:     System Version:        macOS 11.3 (20E232)   Kernel Version:        Darwin 20.4.0   Boot Volume:        Macintosh HD   Boot Mode:        Normal   Computer Name:        mymbp16   User Name:        myusername   Secure Virtual Memory:        Enabled   System Integrity Protection:        Enabled   Time since boot:        1 day 15:54 AppleUSBAudio:     Version:        405.39   Last Modified:        1/1/20, 2:00 AM   Bundle ID:        com.apple.driver.AppleUSBAudio   Notarized:        Yes   Loaded:        Yes   Get Info String:        AppleUSBAudio 405.39, Copyright © 2000-2021 Apple Inc. All rights reserved.   Obtained from:        Apple   Kind:        Universal   Architectures:        arm64e, x86_64   64-Bit (Intel):        Yes   Location:        /System/Library/Extensions/AppleUSBAudio.kext   Kext Version:        405.39   Load Address:        18446743522231001000   Loadable:        Yes   Dependencies:        Satisfied   Signed by:        Software Signing, Apple Code Signing Certification Authority, Apple Root CA

I have a feeling there are many experiencing this issue. Again, glad to see it's not just me. I added your FB number in as a comment to my FB case. For anyone reading, if you have a Feedback Assistant case open, please post it here and I'll add it to my case. Thanks for the reply.

I guess it’s good to hear it’s not just me having the issue. My Feedback Assistant ticket got a reply last week and I have submitted some kernel traces to the ticket per request. I consider that progress. I’ll post any updates I receive as replies to this thread. Thanks for the reply.