I am facing the same issue too. I am a new Mac user and I have my M1 MBP connected to an adaptor for my external monitor and the monitor is like glitching/disconnecting every once in a while (non-deterministic), especially when I am running MS Office (which I had to for work). This is very annoying. I had tried pretty much all the tips - scaled resolution, refresh rate, unchecking TrueTone, and even @black22 red ball. Unfortunately none of these seems to be working :( ... happened even while typing this note. I think I do notice is that it happens with monitor above 1080p resolution. When I use the same adaptor on a 1080p monitor, it didn't glitch a single time :O ... this pretty much renders the hires monitor useless :( :( Should I regret switching from Windows to Mac ...hoping to get a better experience ;) ... oh btw ... I have been using (and am still using) this hires monitor with my Surface Pro with absolutely no issue at all .. so it is not a monitor problem. Any other thoughts on how this can be fixed?