I have had this happening for months now. This is becoming a daily pain to deal with at office now given how often I have to undock my MBP and move around. I finally got frustrated enough to reset my NVRAM/erase disk/reinstall Big Sur and it happened again immediately before I even starting reinstalling software. It was bad enough having to unplug/replug the dock to just get my second monitor active again in the past. The kernel panics have made this so much worse. I am using a CalDigit USB-C Pro Dock at work and a CalDigit TS3 Plus Thunderbolt 3 Dock at home, both cause the issue. 1672: 0xfffffffe00000000 Backtrace (CPU 3), Frame : Return Address 0xffffffb0e409ac10 : 0xffffff801c48e0dd 0xffffffb0e409ac60 : 0xffffff801c5d4f33 0xffffffb0e409aca0 : 0xffffff801c5c552a 0xffffffb0e409acf0 : 0xffffff801c432a2f 0xffffffb0e409ad10 : 0xffffff801c48d8fd 0xffffffb0e409ae30 : 0xffffff801c48dbf3 0xffffffb0e409aea0 : 0xffffff801cc9d81a 0xffffffb0e409af10 : 0xffffff801cc9f846 0xffffffb0e409b390 : 0xffffff801c4ecad6 0xffffffb0e409b400 : 0xffffff801c49d6bc 0xffffffb0e409b450 : 0xffffff801cbae4f2 0xffffffb0e409b470 : 0xffffff801f55a41c 0xffffffb0e409b490 : 0xffffff801f5683fc 0xffffffb0e409b4f0 : 0xffffff801f55ab6e 0xffffffb0e409b590 : 0xffffff801f55cce7 0xffffffb0e409b840 : 0xffffff801f55b073 0xffffffb0e409b9a0 : 0xffffff801f56b882 0xffffffb0e409bbb0 : 0xffffff801f56b564 0xffffffb0e409bed0 : 0xffffff801cc79f5e 0xffffffb0e409bf40 : 0xffffff801cb3fc9e 0xffffffb0e409bfa0 : 0xffffff801c4331f6 Kernel Extensions in backtrace: com.apple.security.sandbox(300.0)[C7CC6439-6854-33FB-9E97-F468B75AD280]@0xffffff801f549000->0xffffff801f58efff dependency: com.apple.driver.AppleMobileFileIntegrity(1.0.5)[366C7BD4-9502-3D1C-ABBE-DE9749913D0C]@0xffffff801dac0000->0xffffff801dad5fff dependency: com.apple.iokit.IOStorageFamily(2.1)[A0D72FE9-649B-316A-8B5C-934E295FF0B5]@0xffffff801f06d000->0xffffff801f07efff dependency: com.apple.kext.AppleMatch(1.0.0d1)[759DEBDE-C844-3703-A01C-4DF5EEA8F4ED]@0xffffff801dabc000->0xffffff801dabefff Process name corresponding to current thread: mds Boot args: chunklist-security-epoch=0 -chunklist-no-rev2-dev Mac OS version: 20F71 Kernel version: Darwin Kernel Version 20.5.0: Sat May 8 05:10:33 PDT 2021; root:xnu-7195.121.3~9/RELEASE_X86_64 Kernel UUID: 52A1E876-863E-38E3-AC80-09BBAB13B752 KernelCache slide: 0x000000001c200000 KernelCache base: 0xffffff801c400000 Kernel slide: 0x000000001c210000 Kernel text base: 0xffffff801c410000 __HIB text base: 0xffffff801c300000 System model name: MacBookPro16,1 (Mac-E1008331FDC96864) System shutdown begun: NO Hibernation exit count: 0 System uptime in nanoseconds: 5557308287228 Last Sleep: absolute base_tsc base_nano Uptime : 0x0000050de962eb77 Sleep : 0x00000360d7e59ac6 0x0000819188b511fa 0x0000035e0cc98a3f Wake : 0x000003610ac134ae 0x000081dd606e7b8c 0x00000360e9e6e12e last started kext at 5485587191614: >usb.cdc.acm 5.0.0 (addr 0xffffff7fb6fa2000, size 8192) last stopped kext at 4030580153044: >usb.serial 6.0.0 (addr 0xffffff7fb700c000, size 20480)