After having tried many solutions, this has worked! For future reference, the issue I was experiencing was with the "Spoken Content" accessibility feature starting to glitch and pause the audio. I could see multiple instances of the coreaudiod process outputting the following in Console.app: coreaudiod Audio IO Overload thread: 5debaa inputs: '<private>' outputs: '<private>' cause: 'Unknown' prewarming: no recovering: no default 09:13:49.765045+0100 coreaudiod CAReportingClient.mm:508 message { HostApplicationDisplayID = Unknown; cause = PageFaultsOffIOThread; deadline = 30204924; "input_device_source_list" = ""; "input_device_transport_list" = ""; "input_device_uid_list" = ""; "io_buffer_size" = 512; "io_cycle" = 789; "io_page_faults" = 0; "is_prewarming" = 0; "is_recovering" = 0; "issue_type" = overload; lateness = 198; "other_page_faults" = 47; "output_device_source_list" = Unknown; "output_device_transport_list" = Bluetooth; "output_device_uid_list" = "C:output"; "sample_rate" = 48000; "smallest_buffer_frame_size" = 512; }: ( 1829656068372 )