I have the same issue here. My config is below: MacBook Pro (16-inch, 2019) 2.6 GHz 6-Core Intel Core i7 6 GB 2667 MHz DDR4 AMD Radeon Pro 5300M 4 GB Intel UHD Graphics 630 1536 MB Every day I have "unexpected" crashes 3-6 times daily, after I install the new macOS Monterey. It was running great on BigSur I am running two monitors plus a retina. Just spoke with Apple, and opened a case, and they did some troubleshooting which was pressing "options+command+p+r" and the PC restarts two times and that was it. I sent them my crash report, and they did not take a look at it at all to see if what is the issue. I am sending to "Apple" support every crash, but no fix so far. This is so far for the last month. It is so annoying to reopen, re-login to every app, and lose data too. They said it happens again to reinstall the OS. It happened again after 30 minutes I hung with Apple support, and I do not think it will be resolved with reinstalling the MacOS. C'mon Apple, do something!!!