Guys I want to jump in and give a Big Thank You to the contributors of this thread. I have a Mac Pro 2013 (trashcan) and everytime I would woud try to upgrade to anything past Catalina I would be hit with severe kernel panics and reboots. I was VERY bad. At first I thought it was caused by my Drobo External storage and its accompanying software (the software is needed to communicate with the storage via Thunderbolt) and since I needed my external storage removing it (and thus upgrading) was out of the question. When Monterey came out I thought surely Apple had taken a look at my dozens and dozens of crash report submissions and fixed the issue. Unfortunately this was not the case and my Mac was crippled by reboots and panics. I disconnected the drive and uninstalled the software and drivers and that gave me a brief reprieve but the random restarts returned shortly after. It even did this with a freshly installed version of Monterey and so I knew I was in trouble. I was beginning to fear that a GPU problem was the ultimate root of the matter as these GPUs are said to go bad prematurely. I happened upon this thread as I searched for solutions. Since I had no issues whatsoever on Mavericks-Catalina I reasoned that it was primarily an issue with the OS even if it caused my hardware to misbehave. I followed the steps listed above and changed the name of the offending kext and I havent had a single freeze or reboot since. My monitor has always used thunderbolt (mini-DP to HDMI) so I know its working without issue (at least for putting out video). I will reinstall/reconnect the Drobo software and enclosure in a day or 2 after ensuring I have a stable crash free system. Hope all goes well! Thank you again