The same thing happened to me when I updated to 15.4.1. I am so frustrated. I have an iPhone SE 2020 and it's not even two years old yet. I use my phone to scan a continuous glucose sensor. It worked absolutely fine all day until I did the update. Immediately after I did the update NFC no longer worked. I did trouble shooting over the phone. Then went into a store. At the store the rep assured me that my phone was absolutely great and nothing was wrong with it -- despite the fact that it no longer read my CGM. In the process I tried two different expensive sensors to isolate if the issue was the sensor or the phone. Two sensors didn't work. I then used my son's phone to scan the sensor and it did work. Mind you, these sensors are $70 each and due to this issue I had to waste two of them. Since then I've had to carry two phones with me, mine and my son's old crusty iPhone 7 just so I can monitor my medical device.
After I went to the Apple store and was told my phone was fine, I went to the grocery store a couple of days later and attempted to use Apple Pay. It didn't work.
I returned to the Apple store and by the time all was said and done, three factory resets were done on my phone and a dozen other trouble shooting steps. Finally the apple rep tried to make an apple pay transaction on my phone and it didn't work. Only then did they agree that my NFC was not working.
I'm pretty peeved about this. I am barely out of warranty. I can't read my medical device. My only choice is to spend hundreds on a new phone, carry two phones or purchase an expensive dedicated sensor from Abbott pharmaceuticals. Adding a bit more salt to the wound, I see that Apple has a website set up to explicitly promote the usage of apple products to doctors, medical systems and patients.
Apple: If you are going to market wearable medical technologies to us, they have to reliably work. There are people who could actually die from this issue. It is no joking matter.
Please resolve this issue immediately, offer those affected a fix or an immediate free replacement. Our health and well being has been threatened by a buggy iOS update. This is dangerous in addition to being unfair.