@frameworksengineer I'm also running into this in iOS 15 in a UIKit app. When it happens the textField isn't visible anymore, although I still see it in the View Debugger. I think it happens when I enter some text and then tap outside the textField.
I see the Assert warnings a number of times and also this one:
WARNING: Calling updateFocusIfNeeded while a focus update is in progress. This call will be ignored.
I did what you ask and the UITextField.interactions[UITextInteraction].textInput property is simply the UITextField.
(lldb) po (UITextField*)0x7f9fd7c2d200
<UITextField: 0x7f9fd7c2d200; frame = (0 0; 484 25); opaque = NO; gestureRecognizers = <NSArray: 0x7f9fc685d6f0>; text = '1.99'; borderStyle = None; background = <_UITextFieldNoBackgroundProvider: 0x7f9fe29e0120: textfield=<UITextField 0x7f9fd7c2d200>>; layer = <CALayer: 0x7f9fe29e3f20>>
(lldb) po ((UITextField*)0x7f9fd7c2d200).interactions
<__NSArrayI 0x7f9fccbb1600>(
<UIDragInteraction: 0x7f9fc68702b0>,
<UIDropInteraction: 0x7f9fc6830220>,
<_UITextMenuLinkInteraction: 0x7f9fc6880dd0>,
<UIContextMenuInteraction: 0x7f9fc6881600>,
<_UIClickPresentationInteraction: 0x7f9fc68819e0>,
<UIPointerInteraction: 0x7f9fc6875dc0>,
<_UIKeyboardBasedTextSelectionInteraction: 0x7f9fc4b71ef0>,
<UITextInteraction: 0x7f9fc4b905a0>,
<UITextLoupeInteraction: 0x7f9fc4b52d10>,
<UITextSelectionInteraction: 0x7f9fc4be4620>,
<UITextIndirectKeyboardInteraction: 0x7f9fc4bfed80>,
<UITextIndirectEditableInteraction: 0x7f9fe17fc190>,
<UITextLoupeInteraction: 0x7f9fe17c0d70>,
<UITextSelectionInteraction: 0x7f9fdb696510>
)
(lldb) po (UITextInteraction*)0x7f9fc4b905a0
<UITextInteraction: 0x7f9fc4b905a0>
(lldb) po ((UITextInteraction*)0x7f9fc4b905a0).textInput
<UITextField: 0x7f9fd7c2d200; frame = (0 0; 484 25); opaque = NO; gestureRecognizers = <NSArray: 0x7f9fc685d6f0>; text = '1.99'; borderStyle = None; background = <_UITextFieldNoBackgroundProvider: 0x7f9fe29e0120: textfield=<UITextField 0x7f9fd7c2d200>>; layer = <CALayer: 0x7f9fe29e3f20>>