I agree it's a weird bug with Monterey. I ran into the same issue with my external Samsung 4TB SSD. After I upgra ded to Monterey my drive immediately started acting weird and then I received this message "Could not mount “4TB SSD”. (com.apple.DiskManagement.disenter error 49218.)" I've tried all kinds of software including Terminal to force mount and I'm still unable to mount this external drive. I have over a decades worth of family photos in iPhoto on this drive most likely all lost. Thanks MacOS Monterey!