I'm on an MacBook Air (M1, 2020) running macOS Big Sur 11.2.1 (20D74). For me, I had an issue with my printer app. It's a Brother HL-L2395DW. I was able to right click the app, select "Get Info" and then select "Open with Rosetta".
This is only a workaround, as macOS does report it to be a universal app, and it should run natively on M1. But when I look at the file with the "file" command-line program, it reports a "Mach-O universal binary with 2 architectures: [x86_64:Mach-O 64-bit executable x86_64] [arm64e:Mach-O 64-bit executable arm64e]". This seems to be the root of the problem, as non-Apple arm64e apps aren't currently supported on M1 systems without jumping through hoops. But this is getting well beyond my wheelhouse.