I thought I had solved the issue with OneDrive, but NO. I was wrong. It did slow the number of crashes but now it has become more erratic than before. Some things seem to be consistent, though: TimeMachine starts failing to back up Office365 apps begin to crash (and this is due to problems accessing Profiles) Memory hogs say apps should be closed (even though they are not clogging - as seen on Activity Monitor). When trying to reboot before it crashes, computer closes all apps but won't reboot - it gets stuck "after" closing the Finder So you force shut down. When you restart the computer, all your personal logins on browsers are gone, all your Finder Windows are closed (Safari even closes all open windows - and returns to older instances, not the one before restart) and Office apps are able to reopen again. OneDrive may or may not be open. So something happens in the library since it destroys part of the cache and personal data saved on browser.

I managed to solve this problem by resetting OneDrive. From Microsoft: Quit OneDrive. (Select the cloud icon in the top tray, then select Settings  Quit OneDrive.) Find OneDrive in your Applications folder. Right-click OneDrive and select Show Package Contents. Browse to the Contents  Resources folder. Double-click ResetOneDriveApp.command (or ResetOneDriveAppStandalone.command, if you're using the standalone app). Start OneDrive and finish the setup process.

Same issue here, apparently. Computer starts crawling to a halt after "heavy" usage (any video app, for instance, or Music, or Office Apps). Either that or reboots after a few minutes when trying to wake up. And OneDrive always crashes. And indexing NEVER stops. I've got a second screen on Thunderbolt and external HDs through USB. iMac (Retina 5K, 27-inch, 2019), 3,1 GHz 6-Core Intel Core i5, 16 GB 2667 MHz DDR4, Radeon Pro 575X 4 GB panic(cpu 1 caller 0xffffff800b764a25): userspace watchdog timeout: no successful checkins from com.apple.WindowServer in 163 seconds service returned not alive with context : is_alive_func returned unhealthy : WindowServer initialization not complete (post IOKitWaitQuiet) service: com.apple.logd, total successful checkins since load (247328 seconds ago): 24724, last successful checkin: 0 seconds ago service: com.apple.WindowServer, total successful checkins since load (247298 seconds ago): 24713, last successful checkin: 163 seconds ago Backtrace (CPU 1), Frame : Return Address 0xffffffa07c833670 : 0xffffff80084bab4d 0xffffffa07c8336c0 : 0xffffff80085fd7e3 0xffffffa07c833700 : 0xffffff80085ede1a 0xffffffa07c833750 : 0xffffff800845fa2f 0xffffffa07c833770 : 0xffffff80084ba3ed 0xffffffa07c833890 : 0xffffff80084ba6d8 0xffffffa07c833900 : 0xffffff8008cbf004 0xffffffa07c833970 : 0xffffff800b764a25 0xffffffa07c833980 : 0xffffff800b764678 0xffffffa07c8339a0 : 0xffffff8008c4628e 0xffffffa07c8339f0 : 0xffffff800b763ab4 0xffffffa07c833b20 : 0xffffff8008c5045b 0xffffffa07c833c80 : 0xffffff80085a8e51 0xffffffa07c833d90 : 0xffffff80084c0147 0xffffffa07c833e00 : 0xffffff8008496905 0xffffffa07c833e60 : 0xffffff80084ae062 0xffffffa07c833ef0 : 0xffffff80085d1fc3 0xffffffa07c833fa0 : 0xffffff8008460216 Kernel Extensions in backtrace: com.apple.driver.watchdog(1.0)[2C1307C5-FD71-3802-8D68-A67DB24BCB4A]@0xffffff800b763000-0xffffff800b764fff Process name corresponding to current thread: watchdogd Mac OS version: 20D91 Kernel version: Darwin Kernel Version 20.3.0: Thu Jan 21 00:07:06 PST 2021; root:xnu-7195.81.3~1/RELEASE_X86_64 Kernel UUID: C86236B2-4976-3542-80CA-74A6B8B4BA03 KernelCache slide: 0x0000000008200000 KernelCache base: 0xffffff8008400000 Kernel slide: 0x0000000008210000 Kernel text base: 0xffffff8008410000 __HIB text base: 0xffffff8008300000 System model name: iMac19,1 (Mac-AA95B1DDAB278B95) System shutdown begun: NO Panic diags file available: YES (0x0) Hibernation exit count: 0 System uptime in nanoseconds: 247340380335411 Last Sleep: absolute base_tsc base_nano Uptime : 0x0000e0f46b823148 Sleep : 0x0000000000000000 0x0000000000000000 0x0000000000000000 Wake : 0x0000000000000000 0x0000000923bbc998 0x0000000000000000 last started kext at 235011561901553: usb.!UUserHCI 1 (addr 0xffffff7fa8d9f000, size 102400) last stopped kext at 7795567663674: !ASMCRTC 1.0 (addr 0xffffff8009ab1000, size 16384) loaded kexts: com.paragon-software.filesystems.ntfs 17.6.15 usb.!UUserHCI 1 @filesystems.afpfs 11.3 @nke.asp_tcp 8.2 usb.!UHostBillboardDevice 1.0 |SCSITaskUserClient 436.40.6 AudioAUUC 1.70 AGPM 119 !APlatformEnabler 2.7.0d0 X86PlatformShim 1.0.0 @fsplaceholder 1.14.0 @fileutil 20.036.15 !AUpstreamUserClient 3.6.8 @kext.AMDFramebuffer 4.0.2 @filesystems.autofs 3.0 @kext.AMDRadeonX4000 4.0.2 @kext.AMDRadeonServiceManager 4.0.2 !AHDA 283.15 !AGraphicsDevicePolicy 6.2.2 eficheck 1 @AGDCPluginDisplayMetrics 6.2.2 !A!IKBLGraphics 16.0.1 pmtelemetry 1 LuaHardwareAccess 1.0.16 |IOUserEthernet 1.0.1 |IO!BSerialManager 8.0.3d9 @Dont_Steal_Mac_OS_X 7.0.0 !AHV 1 !ADiskImages2 1 !A!ICFLGraphicsFramebuffer 16.0.1 !ASMCLMU 212 !A!ISlowAdaptiveClocking 4.0.0 !AMCCSControl 1.14 @kext.AMD9500!C 4.0.2 !AGFXHDA 100.1.431 !AThunderboltIP 4.0.3 !A!IPCHPMC 2.0.1 !ATopCaseHIDEventDriver 4030.5 !UTopCaseDriver 4030.5 BCMWLANFirmware4378.Hashstore 1 BCMWLANFirmware4377.Hashstore 1 BCMWLANFirmware4364.Hashstore 1 BCMWLANFirmware4355.Hashstore 1 @filesystems.tmpfs 1 @filesystems.hfs.kext 556.60.1 @BootCache 40 @!AFSCompression.!AFSCompressionTypeZlib 1.0.0 @!AFSCompression.!AFSCompressionTypeDataless 1.0.0d1 |!ABCM5701Ethernet 11.0.0 !ASDXC 1.9.0 !ABCMWLANBusInterfacePCIeMac 1 @filesystems.apfs 1677.81.1 !AAHCIPort 346 @private.KextAudit 1.0 !AACPIButtons 6.1 !ARTC 2.0 !ASMBIOS 2.1 !AACPIEC 6.1 !AAPIC 1.7 @!ASystemPolicy 2.0.0 @nke.applicationfirewall 310 |IOKitRegistryCompatibility 1 |EndpointSecurity 1 !AXsanScheme 3 $SecureRemotePassword 1.0 |IOSCSIMultimediaCommandsDevice 436.40.6 |IOBD!S!F 1.8 |IODVD!S!F 1.8 |IOCD!S!F 1.8 !AActuatorDriver 4400.28 @kext.triggers 1.0 @kext.AMDRadeonX4400HWLibs 1.0 @kext.AMDRadeonX4000HWServices 4.0.2 DspFuncLib 283.15 @kext.OSvKernDSPLib 529 !AGraphicsControl 6.2.2 |IOAVB!F 930.1 @plugin.IOgPTPPlugin 900.11 |IOEthernetAVB!C 1.1.0 |IOAccelerator!F2 439.52 @!AGPUWrangler 6.2.2 |IOSlowAdaptiveClocking!F 1.0.0 |IO!BHost!CUARTTransport 8.0.3d9 |IO!BHost!CTransport 8.0.3d9 X86PlatformPlugin 1.0.0 !ASMBus!C 1.0.18d1 !ASMBusPCI 1.0.14d1 @kext.AMDSupport 4.0.2 @!AGraphicsDeviceControl 6.2.2 !AHDA!C 283.15 |IOHDA!F 283.15 |IONDRVSupport 585 |IOGraphics!F 585 |IOAudio!F 300.6.1 @vecLib.kext 1.2.0 !A!ILpssUARTv1 3.0.60 !A!ILpssUARTCommon 3.0.60 !AOnboardSerial 1.0 IOPlatformPlugin!F 6.0.0d8 usb.!UHub 1.2 !AHS!BDriver 4030.5 IO!BHIDDriver 8.0.3d9 usb.IOUSBHostHIDDevice 1.2 !AMultitouchDriver 4400.28 !AInputDeviceSupport 4400.35 !AHIDKeyboard 223 usb.networking 5.0.0 usb.!UHostCompositeDevice 1.2 !AThunderboltPCIDownAdapter 4.1.1 !AThunderboltDPInAdapter 8.1.4 !AThunderboltDPAdapter!F 8.1.4 !AHPM 3.4.4 !A!ILpssI2C!C 3.0.60 !A!ILpssI2C 3.0.60 !A!ILpssDmac 3.0.60 !AThunderboltNHI 7.2.8 |IOThunderbolt!F 9.3.2 !ABSDKextStarter 3 |IOSurface 289.3 @filesystems.hfs.encodings.kext 1 !ABCMWLANCoreMac 1.0.0 |IOSerial!F 11 |IO80211!FV2 1200.12.2b1 |IOSkywalk!F 1 mDNSOffloadUserClient 1.0.1b8 IOImageLoader 1.0.0 corecapture 1.0.4 |IOAHCIBlock!S 332 |IONVMe!F 2.1.0 usb.!UXHCIPCI 1.2 usb.!UXHCI 1.2 |IOAHCI!F 294 |IOUSB!F 900.4.2 !AEFINVRAM 2.1 !AEFIRuntime 2.1 |IOSMBus!F 1.1 |IOHID!F 2.0.0 $!AImage4 3.0.0 |IOTimeSync!F 900.11 |IONetworking!F 3.4 DiskImages 493.0.0 |IO!B!F 8.0.3d9 |IOReport!F 47 |IO!BPacketLogger 8.0.3d9 $quarantine 4 $sandbox 300.0 @kext.!AMatch 1.0.0d1 |CoreAnalytics!F 1 !ASSE 1.0 !AKeyStore 2 !UTDM 511.60.2 |IOUSBMass!SDriver 184.40.6 |IOSCSIBlockCommandsDevice 436.40.6 |IO!S!F 2.1 |IOSCSIArchitectureModel!F 436.40.6 !AMobileFileIntegrity 1.0.5 @kext.CoreTrust 1 !AFDEKeyStore 28.30 !AEffaceable!S 1.0 !ACredentialManager 1.0 KernelRelayHost 1 |IOUSBHost!F 1.2 !UHostMergeProperties 1.2 usb.!UCommon 1.0 !ABusPower!C 1.0 !ASEPManager 1.0.1 IOSlaveProcessor 1 !AACPIPlatform 6.1 !ASMC 3.1.9 |IOPCI!F 2.9 |IOACPI!F 1.4 watchdog 1 @kec.pthread 1 @kec.corecrypto 11.1 @kec.Libm 1