I'll add my me to to the list. Since Big Sur - but not the original release, not sure which one in particular. Several different DNS related issues:
Cisco AnyConnect client 4.9.04043. DNS is routed through the tunnel. Works great. System sleeps because I walk away, tunnel disconnects. Tunnel reconnects upon wake, DNS resolution is broken. HUP the mDNSResponder and everything is back to normal. This never happens if the laptop doesn't sleep.
Safari will randomly have issues with DNS and return NXDOMAIN, even though DNS resolution via dig and ping are working fine. But it doesn't do it with pages that are already cached. Other browsers will work fine when Safari is broken. Need to close Safari and re-open to resolve this issue.
mdiorio
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I'll add a me too to the list. I had 3 entries:
wake at 04/11/2262 19:47:16 by 'com.apple.alarm.user-visible-com.apple.email.SendLaterDelivery' User visible: true
removing them resolved the CPU issue so far.