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Thanks for pointing me to the WWDC video!
It seems that the main difference between arm64 and arm64e is that the latter includes pointer authentication.
Apparently you can use the following command to enable arm64e binaries (after disabling SIP):
sudo nvram boot-args=-arm64e_preview_abi
(I haven't tried it yet myself)
The video also pointed to this guide (only talks about iOS though): https://developer.apple.com/documentation/security/preparing_your_app_to_work_with_pointer_authentication