I think these are the commonalities:
OS: iOS 14.2, iOS 14.3 Beta 1, iOS 14.3 Beta 2
Apps: Any Xamarin.iOS app (even apps that don't use any external dll/nuget libraries crash)
Hardware: Any arm64e cpu device (ex: iPad Pro 11" 1st/2nd gen, iPad Pro 12.9" 3rd/4th gen, iPad 8th gen, iPad Air 3rd/4th gen, iPhone 11, etc)
Deployment: Deployed via any MDM or the Apple Configurator 2 from an App Store source (Ad-hoc .ipa deployment works fine even via MDM or Apple Configurator 2, direct Apple Store app install works fine)
Optikam
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It looks like this is the same issue reported here:
https://developer.apple.com/forums/thread/666399
We are experiencing the same issue. We can confirm that the issue occurs when deploying a Xamarin.iOS AppStore app via MDM to an arm64e device running iOS 14.2.
Tested devices that are affected:
iPad Pro 11" 2nd gen
iPad Pro 12.9" 3rd gen
iPad 8th gen
Tested devices that are not affected:
iPad 5th gen