Hello, the same happened to my system. I placed a small shell script in /usr/local/bin and it worked fine when I call it from the Terminal. After trying to load the launchctl command I got the "Load failed: 5: Input/output error" My plist file was very simple and plutil check was w/o any complains. [mf@Server]:/Users/xyz/Library/LaunchAgents $ launchctl load local.demo.plist Load failed: 5: Input/output error Try running launchctl bootstrap as root for richer errors. 


[mf@Server]:/Users/xyz/Library/LaunchAgents $ plutil local.demo.plist local.demo.plist: OK After moving this script into /Users/xyz/ it worked fine.