I found matching the audio format and bit rate on all of my audio devices to help the random pops/clips occurring during audio playback. This can be done in the "Audio Midi Setup" menu. By default, OSX had some audio devises set to 44.1k and others on 48k, some at 16 bit, others at 24 bit. When I had matched the format and bit rate on all connected audio devices to 48k and 24 bit, the pops and clips were reduced dramatically. I would also note my device did not operate well at 44.1k. I would also recommend disabling bluetooth devices, as this has been known to cause issues as well. Hope this helps my fellow audio lovers experiencing these clip/pop playback issues.