Faced to similar issue after upgrading to Monterey (iMac 2017): cracking noice and terrible quality in WhatsApp/Zoom/Discord/Skype/Meet. While playing music or watching youtube it's all ok. Tried to decrease format of used output in Audio MIDI setup app to 44,1 GHz 2ch 64-bit - and it helped perfectly - have clear voice calls again.
Alhana
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