Issues with some USB 2.0 peripherals attached by USB are a known bug:
USB storage devices, including internal SD card readers, may become unavailable after system sleep and require either re-plug or restart to recover.
USB 1.0, 1.1 and older 2.0 devices may not function"
USB Audio drops sporadically in latest Beta. Unplugging and re-plugging reastores for a while.