I'm experiencing the same problem, on both my Macbook and Mac Pro. XIBs are, ostensibly, uneditable when opened with the interface editor. XIBs can be edited when "open as -> source code" fine, but loading the interface builder locks up all XCode UI on my laptop for nearly 30 seconds and makes my Mac Pro unusably laggy.
I've also tried clearing derived data, updating cocoapods, cocoapods projects, ran cleans - seems to effect all projects, including one freshly pulled down from BitBucket. Interface Builder was completely normal in XCode 8.0, but as of updating to 8.1 somehow destroys Xcodes ability to interact with the mouse UI layer.
Other applications fuction normally when the error occurs, CPU usage for XCode is high during the XIB caused slowdown, about 40-60%, similar to JasonGreen; however XCode runs CPU usage of 150-250% during an "Analyze", during which XCode and the UI remain fully responsive, so it's not a matter of limlited CPU ability.
Honest, it feels like some XIB processing task is trying to run on XCodes UI thread...
Anyone have a fix? I don't see widespread panic, so presumably this is only happening with certain library/category/compiler flag/ect...