We are experiencing the same issue. I personally have this happening on two different MacBook's and so far nothing I have tried has allowed me to run Unit Tests from Xcode. This is affecting a MacBook with Mojave and Xcode 9.4.1 and the other MacBook with Mojave and Xcode 10.0.0.
It would appear to be a SIPS violation as Xcode is trying to take over another process (the Simulator) - but as Xcode launched the Simulator it is unclear why it does not have permission to manage it. I also encountered this issue on High Sierra of late, however it was at least prompting the user for 'Admin' credentials, which then allowed Xcode to run the unit tests. On Mojave, no such prompt is appearing.
@Apple - it appears this should be a widespread issue, given the uniformity of the platform and software involved?
EDIT: Found a Radar which dismisses the issue: http://openradar.appspot.com/44945549?_sm_au_=iVVtRsGQkVfRsD6J
EDIT: After seeing the above Radar, I tried Xcode 10 again on Mojave. So far it is running Unit Tests without issue... but will monitor. However, as a developer I am required to still develop using Xcode 9.4.1 for legacy products, so the issue as reported is still blocking development.