I have also this problem with Instruments tool in Xcode 12.4, Xcode 13.1 and Xcode 13.2.4 The device shows properly in the devices and simulators panel, and I'm able to run/debug the product. But when I try to run a leaks analysis the template selection panel says "No device" and the Instrument document gives an "unknown" device selection I tried to clean Developer folder cache, changing how I connect to the device (wirelessly, cable with internet sharing enabled or disabled), but nothing worked.

I have made a fresh setup of macOS Big Sur, then upgraded to Monterey (12.3.1). Still experiencing the same issue with Xcode 13.3.1 and Instruments 13.3.1 (13E500a). As you can see in this picture the device is properly connected. If I open Console.app and filter process with instruments, with the device identifier, I can find two messages with AMDeviceStartSession (thread 0x16f7cf000): Could not start session with device b8e8692a880f964e92702f1da4066121c9e3252e: kAMDNotConnectedError

After hours of investigations, those steps worked for me on this configuration : MacBook Pro (13-inch, M1, 2020) with macOS Monterey 12.3.1 Apple TV 4K (2nd generation) with tvOS 15.6 (19M65) Xcode 13.4.1 Be sure Xcode and Instruments aren’t running Delete all ~/Library/Preferences/com.apple.dt.*.plist files On aTV in Settings > App Remote & Devices you forget the macOS development machine On development machine run  /System/Library/CoreServices/Paired Devices.app and unpair the aTV Open macOS Network Preferences If you don’t have a WiFi service available, skip to step 12 Select the WiFi service Remove it with the minus button Click Apply (this is important) Add the WiFi service you previously removed with the plus (+) button at the bottom left of services list Click Apply (this is important) If you don’t have a LAN Ethernet service available, skip to step 18 Select the LAN Ethernet service Remove it with the minus button Click Apply (this is important) Add the LAN Ethernet service you previously removed with the plus (+) button at the bottom left of services list Click Apply (this is important) Be sure both aTV and development machine are on the same Ethernet or WiFi network On development machine run  /System/Library/CoreServices/Paired Devices.app and pair the aTV If Paired Devices.app display any error, repeat all from step 3 Launch Xcode then open the Devices and Simulators window, you should see the paired aTV Open a tvOS project then Profile