Catalina is not really a problem, is it?
I mean, I can use my old Alesis io26 on Catalina just fine. It's just the Alesis HDM app that won't work because it's 32-bit so the io26 channel routing can only be changed when booting from an earlier OS partition, in my case El Capitan.
I couldn't make the io26 run on Ventura though.