Just chiming in here. Upgraded from Mojave last week. Am experiencing loads of issues with flickering, Finder spontaneously restarting when clicked, exceedingly sluggish app response from Dock, and having to double click to get things to 'happen', etc.
Photoshop, Ableton, Chrome, Music, all randomly ghost, flicker, go semi-transparent, with black bars flashing across the screen as if trying to display every window in finder simultaneously.
Adobe Acrobat is utterly unusable. An epileptic nightmare, especially with a few PDFs in the tabs.
iMac (Retina 5K, 27-inch, 2017). 4.2 GHz Quad-Core Intel Core i7. 64 GB 2400 MHz DDR4. Radeon Pro 580 8 GB. Big Sur 11.4 (20F71). Running a Dell P2715Q.