Instruments Version 12.5 (12E262) on MacOS 11.3.1 (20E241) does not work in a very ominous way:
Required kernel recoding resources in use by another document
Unexpected failure: Tap agent has returned in an unexpected state 'Tap Running'.
Kdebug samplers differ from analysis core spec and ktrace configuration.
Data source agent mishandled a non-blocking rendezvous.
I was wondering if I had a a malware using kdebug to inspect stuff, and reinstalled the OS...
Anyway the old version (12.4) from https://developer.apple.com/download/more/ works
I also submitted a feedback about this.