Same problem here with macOS over the last few months, and still not fixed in Instruments 13.4.1. Some lines are highlighted in the disassembly pane but almost nothing in the source pane.
SantaCruzDad
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According to another thread 13.2.1 is the last version where Instruments Time Profiler still works. It remains broken as of today, in 13.4.1.
Same here - malloc_history seems to be broken?