Having this same issue with my 16" MacBook Pro running Big Sur 11.2.3. Laptop is only about a month old. The two-finger "right click" works, but not a single click. Able to move the mouse around just fine. Connected my Bluetooth Magic Mouse and it works. With Apple Support, directed to reset SMC twice and that temporarily fixed the issue but, after it keeps happening, they're just recommending to bring it in (or mail it in) for service. Hugely annoying! Sounds like it's an issue with Big Sur and really hoping they can get that fixed soon.
RoamingCEO
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