I've just got my m1 air and had this same question, short answer is no I believe other that removing iPad.
Targets Target General Deployment Info macOs - check Mac and you will get the dropdown to select "Scale Interface to match iPad" or "Optimise interface for Mac"
DannyJohnLaw
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This removes the gray background for me on a compact style date picker:
datePicker.subviews[0].subviews[0].subviews[0].alpha = 0